THE BASIC PRINCIPLES OF CH 5450

Inhibitors of Bile Salt Efflux Pump: Keep away from concomitant utilization of inhibitors in the bile salt efflux pump (BSEP) which include cyclosporine. Concomitant drugs that inhibit canalicular membrane bile acid transporters such as the BSEP may well exacerbate accumulation of conjugated bile salts which include taurine conjugate of obeticholi